Inhibitory Mechanism of the CXCR4 Antagonist T22 against Human Immunodeficiency Virus Type 1 Infection

We recently reported that a cationic peptide, T22 ([Tyr(5,12), Lys(7)]-polyphemusin II), specifically inhibits human immunodeficiency virus type 1 (HIV-1) infection mediated by CXCR4 (T. Murakami et al., J. Exp. Med. 186:1389–1393, 1997). Here we demonstrate that T22 effectively inhibits replication...

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Detalhes bibliográficos
Main Authors: Murakami, Tsutomu, Zhang, Tian-Yuan, Koyanagi, Yoshio, Tanaka, Yuetsu, Kim, Jin, Suzuki, Yoichi, Minoguchi, Shigeru, Tamamura, Hirokazu, Waki, Michinori, Matsumoto, Akiyoshi, Fujii, Nobutaka, Shida, Hisatoshi, Hoxie, James A., Peiper, Stephen C., Yamamoto, Naoki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1999
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC104275/
https://ncbi.nlm.nih.gov/pubmed/10438838
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