Conformationally Constrained Analogues of Diacylglycerol. 30. An Investigation of Diacylglycerol-lactones Containing Heteroaryl Groups Reveals Compounds with High Selectivity for Ras Guanyl Nucleotide-Releasing Proteins

Using a diacylglycerol-lactone (DAG-lactone) template previously developed in our laboratory as a scaffold with high binding affinity for C1 domains, we describe herein a series of novel DAG-lactones containing heterocyclic moieties (pyridines, quinolines and indoles) as α-arylidene fragments. Some...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Kazzouli, Saïd El, Lewin, Nancy E., Blumberg, Peter M., Marquez, Victor E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574699/
https://ncbi.nlm.nih.gov/pubmed/18707088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800380b
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky