Conformationally Constrained Analogues of Diacylglycerol. 29. Cells Sort Diacylglycerol-Lactone Chemical Zip Codes to Produce Diverse and Selective Biological Activities

Diacylglycerol-lactone (DAG-lactone) libraries generated by a solid-phase approach using IRORI technology produced a variety of unique biological activities. Subtle differences in chemical diversity in two areas of the molecule, the combination of which generates what we have termed “chemical zip co...

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Autori principali: Duan, Dehui, Sigano, Dina M., Kelley, James A., Lai, Christopher C., Lewin, Nancy E., Kedei, Noemi, Peach, Megan L., Lee, Jeewoo, Abeyweera, Thushara P., Rotenberg, Susan A., Kim, Hee, Kim, Young Ho, Kazzouli, Saïd El, Chung, Jae-Uk, Young, Howard A., Young, Matthew R., Baker, Alyson, Colburn, Nancy H., Haimovitz-Friedman, Adriana, Truman, Jean-Philip, Parrish, Damon A., Deschamps, Jeffrey R., Perry, Nicholas A., Surawski, Robert J., Blumberg, Peter M., Marquez, Victor E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574997/
https://ncbi.nlm.nih.gov/pubmed/18698758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8001907
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