Molecular and cellular insights into T cell exhaustion

von Wherry, E. John, Kurachi, Makoto
Veröffentlicht in Nat Rev Immunol (2015)

Depletion of CD25(+)CD4(+)T cells (Tregs) enhances the HBV-specific CD8(+) T cell response primed by DNA immunization

von Furuichi, Yoshihiro, Tokuyama, Hirotake, Ueha, Satoshi, Kurachi, Makoto, Moriyasu, Fuminori, Kakimi, Kazuhiro
Veröffentlicht in World J Gastroenterol (2005)

MiR-150 regulates memory CD8 T cell differentiation via c-Myb

von Chen, Zeyu, Stelekati, Erietta, Kurachi, Makoto, Yu, Sixiang, Cai, Zhangying, Manne, Sasikanth, Khan, Omar, Yang, Xiaolu, Wherry, E. John
Veröffentlicht in Cell Rep (2017)

Chemokine receptor CXCR3 facilitates CD8(+) T cell differentiation into short-lived effector cells leading to memory degeneration

von Kurachi, Makoto, Kurachi, Junko, Suenaga, Fumiko, Tsukui, Tatsuya, Abe, Jun, Ueha, Satoshi, Tomura, Michio, Sugihara, Kei, Takamura, Shiki, Kakimi, Kazuhiro, Matsushima, Kouji
Veröffentlicht 2011

Lineage-determining transcription factor TCF-1 initiates the epigenetic identity of T cell development

von Johnson, John L., Georgakilas, Georgios, Petrovic, Jelena, Kurachi, Makoto, Cai, Stanley, Harly, Christelle, Pear, Warren S., Bhandoola, Avinash, Wherry, E. John, Vahedi, Golnaz
Veröffentlicht in Immunity (2018)

Optimized retroviral transduction of mouse T cells for in vivo assessment of gene function

von Kurachi, Makoto, Kurachi, Junko, Chen, Zeyu, Johnson, John, Khan, Omar, Bengsch, Bertram, Stelekati, Erietta, Attanasio, John, McLane, Laura M, Tomura, Michio, Ueha, Satoshi, Wherry, E John
Veröffentlicht in Nat Protoc (2017)

Janus kinase inhibition lessens inflammation and ameliorates disease in murine models of hemophagocytic lymphohistiocytosis

von Das, Rupali, Guan, Peng, Sprague, Leslee, Verbist, Katherine, Tedrick, Paige, An, Qi Angel, Cheng, Cheng, Kurachi, Makoto, Levine, Ross, Wherry, E. John, Canna, Scott W., Behrens, Edward M., Nichols, Kim E.
Veröffentlicht in Blood (2016)

Bioenergetic insufficiencies due to metabolic alterations regulated by PD-1 are an early driver of CD8(+) T cell exhaustion

von Bengsch, Bertram, Johnson, Andy L., Kurachi, Makoto, Odorizzi, Pamela M, Pauken, Kristen E., Attanasio, John, Stelekati, Erietta, McLane, Laura M., Paley, Michael A., Delgoffe, Greg M., Wherry, E. John
Veröffentlicht in Immunity (2016)

The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8(+) T cells

von Kurachi, Makoto, Barnitz, R. Anthony, Yosef, Nir, Odorizzi, Pamela M., Dilorio, Michael A., Lemieux, Madeleine E., Yates, Kathleen, Godec, Jernej, Klatt, Martin G., Regev, Aviv, Wherry, E. John, Haining, W. Nicholas
Veröffentlicht 2014

Long-Term Persistence of Exhausted CD8 T Cells in Chronic Infection Is Regulated by MicroRNA-155

von Stelekati, Erietta, Chen, Zeyu, Manne, Sasikanth, Kurachi, Makoto, Ali, Mohammed-Alkhatim, Lewy, Keith, Cai, Zhangying, Nzingha, Kito, McLane, Laura M., Hope, Jennifer L., Fike, Adam J., Katsikis, Peter D., Wherry, E. John
Veröffentlicht in Cell Rep (2018)

Long-Lasting Graft-Derived Donor T Cells Contribute to the Pathogenesis of Chronic Graft-versus-Host Disease in Mice

von Kosugi-Kanaya, Mizuha, Ueha, Satoshi, Abe, Jun, Shichino, Shigeyuki, Shand, Francis H. W., Morikawa, Teppei, Kurachi, Makoto, Shono, Yusuke, Sudo, Naoto, Yamashita, Ai, Suenaga, Fumiko, Yokoyama, Akihiro, Yong, Wang, Imamura, Masahiro, Teshima, Takanori, Matsushima, Kouji
Veröffentlicht in Front Immunol (2017)

CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways

von Wein, Alexander N., McMaster, Sean R., Takamura, Shiki, Dunbar, Paul R., Cartwright, Emily K., Hayward, Sarah L., McManus, Daniel T., Shimaoka, Takeshi, Ueha, Satoshi, Tsukui, Tatsuya, Masumoto, Tomoko, Kurachi, Makoto, Matsushima, Kouji, Kohlmeier, Jacob E.
Veröffentlicht in J Exp Med (2019)

MCPIP1 reduces HBV-RNA by targeting its epsilon structure

von Li, Yingfang, Que, Lusheng, Fukano, Kento, Koura, Miki, Kitamura, Kouichi, Zheng, Xin, Kato, Takanobu, Aly, Hussein Hassan, Watashi, Koichi, Tsukuda, Senko, Aizaki, Hideki, Watanabe, Noriyuki, Sato, Yuko, Suzuki, Tadaki, Suzuki, Hiroshi I., Hosomichi, Kazuyoshi, Kurachi, Makoto, Wakae, Kousho, Muramatsu, Masamichi
Veröffentlicht in Sci Rep (2020)

Trib1 regulates T cell differentiation during chronic infection by restraining the effector program

von Rome, Kelly S., Stein, Sarah J., Kurachi, Makoto, Petrovic, Jelena, Schwartz, Gregory W., Mack, Ethan A., Uljon, Sacha, Wu, Winona W., DeHart, Anne G., McClory, Susan E., Xu, Lanwei, Gimotty, Phyllis A., Blacklow, Stephen C., Faryabi, Robert B., Wherry, E. John, Jordan, Martha S., Pear, Warren S.
Veröffentlicht in J Exp Med (2020)

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

von Pauken, Kristen E., Sammons, Morgan A., Odorizzi, Pamela M., Manne, Sasikanth, Godec, Jernej, Khan, Omar, Drake, Adam M., Chen, Zeyu, Sen, Debattama R., Kurachi, Makoto, Barnitz, R. Anthony, Bartman, Caroline, Bengsch, Bertram, Huang, Alexander C., Schenkel, Jason M., Vahedi, Golnaz, Haining, W. Nicholas, Berger, Shelley L., Wherry, E. John
Veröffentlicht in Science (2016)

The epigenetic landscape of T cell exhaustion

von Sen, Debattama R., Kaminski, James, Barnitz, R. Anthony, Kurachi, Makoto, Gerdemann, Ulrike, Yates, Kathleen B., Tsao, Hsiao-Wei, Godec, Jernej, LaFleur, Martin W., Brown, Flavian D., Tonnerre, Pierre, Chung, Raymond T., Tully, Damien C., Allen, Todd M., Frahm, Nicole, Lauer, Georg M., Wherry, E. John, Yosef, Nir, Haining, W. Nicholas
Veröffentlicht in Science (2016)

TCF-1-centered transcriptional network drives an effector versus exhausted CD8 T cell fate decision

von Chen, Zeyu, Ji, Zhicheng, Ngiow, Shin Foong, Manne, Sasikanth, Cai, Zhangying, Huang, Alexander C., Johnson, John, Staupe, Ryan P., Bengsch, Bertram, Xu, Caiyue, Yu, Sixiang, Kurachi, Makoto, Herati, Ramin S., Vella, Laura A., Baxter, Amy E., Wu, Jennifer E., Khan, Omar, Beltra, Jean-Christophe, Giles, Josephine R., Stelekati, Erietta, McLane, Laura M., Lau, Chi Wai, Yang, Xiaolu, Berger, Shelley L., Vahedi, Golnaz, Ji, Hongkai, Wherry, E. John
Veröffentlicht in Immunity (2019)

In vivo CD8(+) T cell CRISPR screening reveals control by Fli1 in infection and cancer.

von Chen, Zeyu, Arai, Eri, Khan, Omar, Zhang, Zhen, Ngiow, Shin Foong, He, Yuan, Huang, Hua, Manne, Sasikanth, Cao, Zhendong, Baxter, Amy E., Cai, Zhangying, Freilich, Elizabeth, Ali, Mohammed A., Giles, Josephine R., Wu, Jennifer E., Greenplate, Allison R., Hakeem, Mohamed A., Chen, Qingzhou, Kurachi, Makoto, Nzingha, Kito, Ekshyyan, Viktoriya, Mathew, Divij, Wen, Zhuoyu, Speck, Nancy A., Battle, Alexis, Berger, Shelley L., Wherry, E. John, Shi, Junwei
Veröffentlicht in Cell (2021)

Inhibitory signaling sustains a distinct early memory CD8(+) T cell precursor that is resistant to DNA damage

von Johnnidis, Jonathan B., Muroyama, Yuki, Ngiow, Shin Foong, Chen, Zeyu, Manne, Sasikanth, Cai, Zhangying, Song, Shufei, Platt, Jesse M., Schenkel, Jason M., Abdel-Hakeem, Mohamed, Beltra, Jean-Christophe, Greenplate, Allison R., Ali, Mohammed-Alkhatim A., Nzingha, Kito, Giles, Josephine R., Harly, Christelle, Attanasio, John, Pauken, Kristen E., Bengsch, Bertram, Paley, Michael A., Tomov, Vesselin T., Kurachi, Makoto, Vignali, Dario A. A., Sharpe, Arlene H., Reiner, Steven L., Bhandoola, Avinash, Johnson, F. Bradley, Wherry, E. John
Veröffentlicht in Sci Immunol (2021)

Group 1 Innate lymphoid cell lineage identity is determined by a cis-regulatory element marked by a long non-coding RNA

von Mowel, Walter K., McCright, Sam J., Kotzin, Jonathan J., Collet, Magalie A., Uyar, Asli, Chen, Xin, DeLaney, Alexandra, Spencer, Sean P., Virtue, Anthony T., Yang, EnJun, Villarino, Alejandro, Kurachi, Makoto, Dunagin, Margaret C., Pritchard, Gretchen Harms, Stein, Judith, Hughes, Cynthia, Fonseca-Pereira, Diogo, Veiga-Fernandes, Henrique, Raj, Arjun, Kambayashi, Taku, Brodsky, Igor E., O’Shea, John J., Wherry, E. John, Goff, Loyal A., Rinn, John L., Williams, Adam, Flavell, Richard A., Henao-Mejia, Jorge
Veröffentlicht in Immunity (2017)