Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

Blocking Programmed Death–1 (PD-1) can reinvigorate exhausted CD8 Tcells (T(EX)) and improve control of chronic infections and cancer. However, whether blocking PD-1 can reprogram T(EX) into durable memory Tcells (T(MEM)) is unclear. We found that reinvigoration of T(EX) in mice by PD-L1 blockade ca...

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Gepubliceerd in:Science
Hoofdauteurs: Pauken, Kristen E., Sammons, Morgan A., Odorizzi, Pamela M., Manne, Sasikanth, Godec, Jernej, Khan, Omar, Drake, Adam M., Chen, Zeyu, Sen, Debattama R., Kurachi, Makoto, Barnitz, R. Anthony, Bartman, Caroline, Bengsch, Bertram, Huang, Alexander C., Schenkel, Jason M., Vahedi, Golnaz, Haining, W. Nicholas, Berger, Shelley L., Wherry, E. John
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484795/
https://ncbi.nlm.nih.gov/pubmed/27789795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf2807
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