Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

Blocking Programmed Death–1 (PD-1) can reinvigorate exhausted CD8 Tcells (T(EX)) and improve control of chronic infections and cancer. However, whether blocking PD-1 can reprogram T(EX) into durable memory Tcells (T(MEM)) is unclear. We found that reinvigoration of T(EX) in mice by PD-L1 blockade ca...

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Publicado no:Science
Main Authors: Pauken, Kristen E., Sammons, Morgan A., Odorizzi, Pamela M., Manne, Sasikanth, Godec, Jernej, Khan, Omar, Drake, Adam M., Chen, Zeyu, Sen, Debattama R., Kurachi, Makoto, Barnitz, R. Anthony, Bartman, Caroline, Bengsch, Bertram, Huang, Alexander C., Schenkel, Jason M., Vahedi, Golnaz, Haining, W. Nicholas, Berger, Shelley L., Wherry, E. John
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484795/
https://ncbi.nlm.nih.gov/pubmed/27789795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf2807
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