Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

Blocking Programmed Death–1 (PD-1) can reinvigorate exhausted CD8 Tcells (T(EX)) and improve control of chronic infections and cancer. However, whether blocking PD-1 can reprogram T(EX) into durable memory Tcells (T(MEM)) is unclear. We found that reinvigoration of T(EX) in mice by PD-L1 blockade ca...

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Published in:Science
Main Authors: Pauken, Kristen E., Sammons, Morgan A., Odorizzi, Pamela M., Manne, Sasikanth, Godec, Jernej, Khan, Omar, Drake, Adam M., Chen, Zeyu, Sen, Debattama R., Kurachi, Makoto, Barnitz, R. Anthony, Bartman, Caroline, Bengsch, Bertram, Huang, Alexander C., Schenkel, Jason M., Vahedi, Golnaz, Haining, W. Nicholas, Berger, Shelley L., Wherry, E. John
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484795/
https://ncbi.nlm.nih.gov/pubmed/27789795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf2807
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