Molecular and cellular insights into T cell exhaustion

Por Wherry, E. John, Kurachi, Makoto
Publicado no Nat Rev Immunol (2015)

Depletion of CD25(+)CD4(+)T cells (Tregs) enhances the HBV-specific CD8(+) T cell response primed by DNA immunization

Por Furuichi, Yoshihiro, Tokuyama, Hirotake, Ueha, Satoshi, Kurachi, Makoto, Moriyasu, Fuminori, Kakimi, Kazuhiro
Publicado no World J Gastroenterol (2005)

MiR-150 regulates memory CD8 T cell differentiation via c-Myb

Por Chen, Zeyu, Stelekati, Erietta, Kurachi, Makoto, Yu, Sixiang, Cai, Zhangying, Manne, Sasikanth, Khan, Omar, Yang, Xiaolu, Wherry, E. John
Publicado no Cell Rep (2017)

Chemokine receptor CXCR3 facilitates CD8(+) T cell differentiation into short-lived effector cells leading to memory degeneration

Por Kurachi, Makoto, Kurachi, Junko, Suenaga, Fumiko, Tsukui, Tatsuya, Abe, Jun, Ueha, Satoshi, Tomura, Michio, Sugihara, Kei, Takamura, Shiki, Kakimi, Kazuhiro, Matsushima, Kouji
Publicado em 2011

Lineage-determining transcription factor TCF-1 initiates the epigenetic identity of T cell development

Por Johnson, John L., Georgakilas, Georgios, Petrovic, Jelena, Kurachi, Makoto, Cai, Stanley, Harly, Christelle, Pear, Warren S., Bhandoola, Avinash, Wherry, E. John, Vahedi, Golnaz
Publicado no Immunity (2018)

Optimized retroviral transduction of mouse T cells for in vivo assessment of gene function

Por Kurachi, Makoto, Kurachi, Junko, Chen, Zeyu, Johnson, John, Khan, Omar, Bengsch, Bertram, Stelekati, Erietta, Attanasio, John, McLane, Laura M, Tomura, Michio, Ueha, Satoshi, Wherry, E John
Publicado no Nat Protoc (2017)

Janus kinase inhibition lessens inflammation and ameliorates disease in murine models of hemophagocytic lymphohistiocytosis

Por Das, Rupali, Guan, Peng, Sprague, Leslee, Verbist, Katherine, Tedrick, Paige, An, Qi Angel, Cheng, Cheng, Kurachi, Makoto, Levine, Ross, Wherry, E. John, Canna, Scott W., Behrens, Edward M., Nichols, Kim E.
Publicado no Blood (2016)

Bioenergetic insufficiencies due to metabolic alterations regulated by PD-1 are an early driver of CD8(+) T cell exhaustion

Por Bengsch, Bertram, Johnson, Andy L., Kurachi, Makoto, Odorizzi, Pamela M, Pauken, Kristen E., Attanasio, John, Stelekati, Erietta, McLane, Laura M., Paley, Michael A., Delgoffe, Greg M., Wherry, E. John
Publicado no Immunity (2016)

The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8(+) T cells

Por Kurachi, Makoto, Barnitz, R. Anthony, Yosef, Nir, Odorizzi, Pamela M., Dilorio, Michael A., Lemieux, Madeleine E., Yates, Kathleen, Godec, Jernej, Klatt, Martin G., Regev, Aviv, Wherry, E. John, Haining, W. Nicholas
Publicado em 2014

Long-Term Persistence of Exhausted CD8 T Cells in Chronic Infection Is Regulated by MicroRNA-155

Por Stelekati, Erietta, Chen, Zeyu, Manne, Sasikanth, Kurachi, Makoto, Ali, Mohammed-Alkhatim, Lewy, Keith, Cai, Zhangying, Nzingha, Kito, McLane, Laura M., Hope, Jennifer L., Fike, Adam J., Katsikis, Peter D., Wherry, E. John
Publicado no Cell Rep (2018)

Long-Lasting Graft-Derived Donor T Cells Contribute to the Pathogenesis of Chronic Graft-versus-Host Disease in Mice

Por Kosugi-Kanaya, Mizuha, Ueha, Satoshi, Abe, Jun, Shichino, Shigeyuki, Shand, Francis H. W., Morikawa, Teppei, Kurachi, Makoto, Shono, Yusuke, Sudo, Naoto, Yamashita, Ai, Suenaga, Fumiko, Yokoyama, Akihiro, Yong, Wang, Imamura, Masahiro, Teshima, Takanori, Matsushima, Kouji
Publicado no Front Immunol (2017)

CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways

Por Wein, Alexander N., McMaster, Sean R., Takamura, Shiki, Dunbar, Paul R., Cartwright, Emily K., Hayward, Sarah L., McManus, Daniel T., Shimaoka, Takeshi, Ueha, Satoshi, Tsukui, Tatsuya, Masumoto, Tomoko, Kurachi, Makoto, Matsushima, Kouji, Kohlmeier, Jacob E.
Publicado no J Exp Med (2019)

MCPIP1 reduces HBV-RNA by targeting its epsilon structure

Por Li, Yingfang, Que, Lusheng, Fukano, Kento, Koura, Miki, Kitamura, Kouichi, Zheng, Xin, Kato, Takanobu, Aly, Hussein Hassan, Watashi, Koichi, Tsukuda, Senko, Aizaki, Hideki, Watanabe, Noriyuki, Sato, Yuko, Suzuki, Tadaki, Suzuki, Hiroshi I., Hosomichi, Kazuyoshi, Kurachi, Makoto, Wakae, Kousho, Muramatsu, Masamichi
Publicado no Sci Rep (2020)

Trib1 regulates T cell differentiation during chronic infection by restraining the effector program

Por Rome, Kelly S., Stein, Sarah J., Kurachi, Makoto, Petrovic, Jelena, Schwartz, Gregory W., Mack, Ethan A., Uljon, Sacha, Wu, Winona W., DeHart, Anne G., McClory, Susan E., Xu, Lanwei, Gimotty, Phyllis A., Blacklow, Stephen C., Faryabi, Robert B., Wherry, E. John, Jordan, Martha S., Pear, Warren S.
Publicado no J Exp Med (2020)

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

Por Pauken, Kristen E., Sammons, Morgan A., Odorizzi, Pamela M., Manne, Sasikanth, Godec, Jernej, Khan, Omar, Drake, Adam M., Chen, Zeyu, Sen, Debattama R., Kurachi, Makoto, Barnitz, R. Anthony, Bartman, Caroline, Bengsch, Bertram, Huang, Alexander C., Schenkel, Jason M., Vahedi, Golnaz, Haining, W. Nicholas, Berger, Shelley L., Wherry, E. John
Publicado no Science (2016)

The epigenetic landscape of T cell exhaustion

Por Sen, Debattama R., Kaminski, James, Barnitz, R. Anthony, Kurachi, Makoto, Gerdemann, Ulrike, Yates, Kathleen B., Tsao, Hsiao-Wei, Godec, Jernej, LaFleur, Martin W., Brown, Flavian D., Tonnerre, Pierre, Chung, Raymond T., Tully, Damien C., Allen, Todd M., Frahm, Nicole, Lauer, Georg M., Wherry, E. John, Yosef, Nir, Haining, W. Nicholas
Publicado no Science (2016)

TCF-1-centered transcriptional network drives an effector versus exhausted CD8 T cell fate decision

Por Chen, Zeyu, Ji, Zhicheng, Ngiow, Shin Foong, Manne, Sasikanth, Cai, Zhangying, Huang, Alexander C., Johnson, John, Staupe, Ryan P., Bengsch, Bertram, Xu, Caiyue, Yu, Sixiang, Kurachi, Makoto, Herati, Ramin S., Vella, Laura A., Baxter, Amy E., Wu, Jennifer E., Khan, Omar, Beltra, Jean-Christophe, Giles, Josephine R., Stelekati, Erietta, McLane, Laura M., Lau, Chi Wai, Yang, Xiaolu, Berger, Shelley L., Vahedi, Golnaz, Ji, Hongkai, Wherry, E. John
Publicado no Immunity (2019)

Group 1 Innate lymphoid cell lineage identity is determined by a cis-regulatory element marked by a long non-coding RNA

Por Mowel, Walter K., McCright, Sam J., Kotzin, Jonathan J., Collet, Magalie A., Uyar, Asli, Chen, Xin, DeLaney, Alexandra, Spencer, Sean P., Virtue, Anthony T., Yang, EnJun, Villarino, Alejandro, Kurachi, Makoto, Dunagin, Margaret C., Pritchard, Gretchen Harms, Stein, Judith, Hughes, Cynthia, Fonseca-Pereira, Diogo, Veiga-Fernandes, Henrique, Raj, Arjun, Kambayashi, Taku, Brodsky, Igor E., O’Shea, John J., Wherry, E. John, Goff, Loyal A., Rinn, John L., Williams, Adam, Flavell, Richard A., Henao-Mejia, Jorge
Publicado no Immunity (2017)