TCF-1-centered transcriptional network drives an effector versus exhausted CD8 T cell fate decision

TCF-1 is a key transcription factor in progenitor exhausted CD8 T cells (Tex). Moreover, this Tex cell subset mediates responses to PD-1 checkpoint pathway blockade. However, the role of the transcription factor TCF-1 in early fate decisions and initial generation of Tex cells is unclear. Single cel...

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Publicado no:Immunity
Main Authors: Chen, Zeyu, Ji, Zhicheng, Ngiow, Shin Foong, Manne, Sasikanth, Cai, Zhangying, Huang, Alexander C., Johnson, John, Staupe, Ryan P., Bengsch, Bertram, Xu, Caiyue, Yu, Sixiang, Kurachi, Makoto, Herati, Ramin S., Vella, Laura A., Baxter, Amy E., Wu, Jennifer E., Khan, Omar, Beltra, Jean-Christophe, Giles, Josephine R., Stelekati, Erietta, McLane, Laura M., Lau, Chi Wai, Yang, Xiaolu, Berger, Shelley L., Vahedi, Golnaz, Ji, Hongkai, Wherry, E. John
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6943829/
https://ncbi.nlm.nih.gov/pubmed/31606264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.09.013
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