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Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation
Exhausted CD8 T cells (T(EX)) are a distinct state of T cell differentiation associated with failure to clear chronic viruses and cancer. Immunotherapies like PD-1 blockade can re-invigorate T(EX) cells, but re-invigoration is not durable. A major unanswered question is whether T(EX) cells different...
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| 出版年: | Nat Immunol |
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| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8323971/ https://ncbi.nlm.nih.gov/pubmed/34312545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-021-00975-5 |
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