Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation

Exhausted CD8 T cells (T(EX)) are a distinct state of T cell differentiation associated with failure to clear chronic viruses and cancer. Immunotherapies like PD-1 blockade can re-invigorate T(EX) cells, but re-invigoration is not durable. A major unanswered question is whether T(EX) cells different...

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Veröffentlicht in:Nat Immunol
Hauptverfasser: Abdel-Hakeem, Mohamed S., Manne, Sasikanth, Beltra, Jean-Christophe, Stelekati, Erietta, Chen, Zeyu, Nzingha, Kito, Ali, Mohammed-Alkhatim, Johnson, John L., Giles, Josephine R., Mathew, Divij, Greenplate, Allison R., Vahedi, Golnaz, Wherry, E. John
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8323971/
https://ncbi.nlm.nih.gov/pubmed/34312545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-021-00975-5
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