TCF-1-centered transcriptional network drives an effector versus exhausted CD8 T cell fate decision

TCF-1 is a key transcription factor in progenitor exhausted CD8 T cells (Tex). Moreover, this Tex cell subset mediates responses to PD-1 checkpoint pathway blockade. However, the role of the transcription factor TCF-1 in early fate decisions and initial generation of Tex cells is unclear. Single cel...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Immunity
Autori principali: Chen, Zeyu, Ji, Zhicheng, Ngiow, Shin Foong, Manne, Sasikanth, Cai, Zhangying, Huang, Alexander C., Johnson, John, Staupe, Ryan P., Bengsch, Bertram, Xu, Caiyue, Yu, Sixiang, Kurachi, Makoto, Herati, Ramin S., Vella, Laura A., Baxter, Amy E., Wu, Jennifer E., Khan, Omar, Beltra, Jean-Christophe, Giles, Josephine R., Stelekati, Erietta, McLane, Laura M., Lau, Chi Wai, Yang, Xiaolu, Berger, Shelley L., Vahedi, Golnaz, Ji, Hongkai, Wherry, E. John
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6943829/
https://ncbi.nlm.nih.gov/pubmed/31606264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.09.013
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi