Bioenergetic insufficiencies due to metabolic alterations regulated by PD-1 are an early driver of CD8(+) T cell exhaustion

Dynamic reprogramming of metabolism is essential for T cell effector function and memory formation. However, the regulation of metabolism in exhausted CD8(+) T (Tex) cells is poorly understood. We found that during the first week of chronic lymphocytic choriomeningitis virus (LCMV) infection, before...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Bengsch, Bertram, Johnson, Andy L., Kurachi, Makoto, Odorizzi, Pamela M, Pauken, Kristen E., Attanasio, John, Stelekati, Erietta, McLane, Laura M., Paley, Michael A., Delgoffe, Greg M., Wherry, E. John
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4988919/
https://ncbi.nlm.nih.gov/pubmed/27496729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.07.008
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