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Overcoming T cell exhaustion in infection and cancer

Inhibitors of the PD-1:PD-L1 pathway, a central regulator of T cell exhaustion, have been recently shown to be effective for treatment of different cancers. However, clinical responses are mixed, highlighting the need to better understand the mechanisms of action of PD-1:PD-L1, the role of this path...

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Bibliografski detalji
Izdano u:Trends Immunol
Glavni autori: Pauken, Kristen E., Wherry, E. John
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4393798/
https://ncbi.nlm.nih.gov/pubmed/25797516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.it.2015.02.008
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