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T Cell Exhaustion During Persistent Viral Infections

Although robust and highly effective anti-viral T cells contribute to the clearance of many acute infections, viral persistence is associated with the development of functionally inferior, exhausted, T cell responses. Exhaustion develops in a step-wise and progressive manner, ranges in severity, and...

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Bibliografiske detaljer
Udgivet i:Virology
Main Authors: Kahan, Shannon M., Wherry, E. John, Zajac, Allan J.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4424083/
https://ncbi.nlm.nih.gov/pubmed/25620767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2014.12.033
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