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CD8(+) T cell exhaustion during persistent viral infection is regulated independently of the virus-specific T cell receptor
During chronic viral infections, responses by virus-specific CD8(+) T cells become marginalized by the acquisition of functional defects and reduced cell numbers in a process defined as T cell exhaustion. T cell tolerance to self-antigen is also characterized by impaired effector function and eventu...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3595333/ https://ncbi.nlm.nih.gov/pubmed/23461613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/08820139.2012.751397 |
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