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CD8(+) T cell exhaustion during persistent viral infection is regulated independently of the virus-specific T cell receptor

During chronic viral infections, responses by virus-specific CD8(+) T cells become marginalized by the acquisition of functional defects and reduced cell numbers in a process defined as T cell exhaustion. T cell tolerance to self-antigen is also characterized by impaired effector function and eventu...

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Detalhes bibliográficos
Main Authors: Jackson, Stephanie R., Berrien-Elliott, Melissa M., Meyer, Jennifer M., Wherry, E. John, Teague, Ryan M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595333/
https://ncbi.nlm.nih.gov/pubmed/23461613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/08820139.2012.751397
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