Janus kinase inhibition lessens inflammation and ameliorates disease in murine models of hemophagocytic lymphohistiocytosis

Hemophagocytic lymphohistiocytosis (HLH) comprises an emerging spectrum of inherited and noninherited disorders of the immune system characterized by the excessive production of cytokines, including interferon-γ and interleukins 2, 6, and 10 (IL-2, IL-6, and IL-10). The Janus kinases (JAKs) transduc...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Das, Rupali, Guan, Peng, Sprague, Leslee, Verbist, Katherine, Tedrick, Paige, An, Qi Angel, Cheng, Cheng, Kurachi, Makoto, Levine, Ross, Wherry, E. John, Canna, Scott W., Behrens, Edward M., Nichols, Kim E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817310/
https://ncbi.nlm.nih.gov/pubmed/26825707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-12-684399
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