Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

Blocking Programmed Death–1 (PD-1) can reinvigorate exhausted CD8 Tcells (T(EX)) and improve control of chronic infections and cancer. However, whether blocking PD-1 can reprogram T(EX) into durable memory Tcells (T(MEM)) is unclear. We found that reinvigoration of T(EX) in mice by PD-L1 blockade ca...

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Bibliografiska uppgifter
I publikationen:Science
Huvudupphovsmän: Pauken, Kristen E., Sammons, Morgan A., Odorizzi, Pamela M., Manne, Sasikanth, Godec, Jernej, Khan, Omar, Drake, Adam M., Chen, Zeyu, Sen, Debattama R., Kurachi, Makoto, Barnitz, R. Anthony, Bartman, Caroline, Bengsch, Bertram, Huang, Alexander C., Schenkel, Jason M., Vahedi, Golnaz, Haining, W. Nicholas, Berger, Shelley L., Wherry, E. John
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484795/
https://ncbi.nlm.nih.gov/pubmed/27789795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf2807
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