A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activity

Por Magrioti, Victoria, Naxakis, George, Hadjipavlou-Litina, Dimitra, Makriyannis, Alexandros, Kokotos, George
Publicado em 2008

Phospholipase A(2) Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention

Por Dennis, Edward A., Cao, Jian, Hsu, Yuan-Hao, Magrioti, Victoria, Kokotos, George
Publicado em 2011

Synthesis of 2-oxoamides based on sulfonamide analogues of γ-amino acids and their activity on phospholipase A(2)

Por Antonopoulou, Georgia, Magrioti, Victoria, Stephens, Daren, Constantinou-Kokotou, Violetta, Dennis, Edward A., Kokotos, George
Publicado em 2008

Binding Conformation of 2-Oxoamide Inhibitors to Group IVA Cytosolic Phospholipase A(2) Determined by Molecular Docking Combined with Molecular Dynamics

Por Mouchlis, Varnavas D., Michopoulou, Vasiliki, Constantinou-Kokotou, Violetta, Mavromoustakos, Thomas, Dennis, Edward A., Kokotos, George
Publicado em 2012

Synthesis of Polyfluoro Ketones for Selective Inhibition of Human Phospholipase A(2) Enzymes

Por Baskakis, Constantinos, Magrioti, Victoria, Cotton, Naomi, Stephens, Daren, Constantinou-Kokotou, Violetta, Dennis, Edward A., Kokotos, George
Publicado em 2008

Characterization of FKGK18 as Inhibitor of Group VIA Ca(2+)-Independent Phospholipase A(2) (iPLA(2)β): Candidate Drug for Preventing Beta-Cell Apoptosis and Diabetes

Por Ali, Tomader, Kokotos, George, Magrioti, Victoria, Bone, Robert N., Mobley, James A., Hancock, William, Ramanadham, Sasanka
Publicado em 2013

New potent and selective polyfluoroalkyl ketone inhibitors of GVIA calcium-independent phospholipase A2

Por Magrioti, Victoria, Nikolaou, Aikaterini, Smyrniotou, Annetta, Shah, Ishita, Constantinou-Kokotou, Violetta, Dennis, Edward A., Kokotos, George
Publicado em 2013

Development of a potent 2-oxoamide inhibitor of secreted phospholipase A(2) guided by molecular docking calculations and molecular dynamics simulations

Por Vasilakaki, Sofia, Barbayianni, Efrosini, Leonis, Georgios, Papadopoulos, Manthos G., Mavromoustakos, Thomas, Gelb, Michael H., Kokotos, George
Publicado no Bioorg Med Chem (2016)

Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2) enzymes

Por Antonopoulou, Georgia, Barbayianni, Efrosini, Magrioti, Victoria, Cotton, Naomi, Stephens, Daren, Constantinou-Kokotou, Violetta, Dennis, Edward A., Kokotos, George
Publicado em 2008

Potent and Selective Fluoroketone Inhibitors of Group VIA Calcium-Independent Phospholipase A(2)

Por Kokotos, George, Hsu, Yuan-Hao, Burke, John E., Baskakis, Constantinos, Kokotos, Christoforos G., Magrioti, Victoria, Dennis, Edward A.
Publicado em 2010

2-Oxoamides based on dipeptides as selective calcium-independent phospholipase A(2) inhibitors

Por Smyrniotou, Anneta, Kokotou, Maroula G., Mouchlis, Varnavas D., Barbayianni, Efrosini, Kokotos, George, Dennis, Edward A., Constantinou-Kokotou, Violetta
Publicado no Bioorg Med Chem (2016)

Development of Potent and Selective Inhibitors for Group VIA Calcium-Independent Phospholipase A(2) Guided by Molecular Dynamics and Structure-Activity Relationships

Por Mouchlis, Varnavas D., Limnios, Dimitris, Kokotou, Maroula G., Barbayianni, Efrosini, Kokotos, George, McCammon, J. Andrew, Dennis, Edward A.
Publicado no J Med Chem (2016)

2-Oxoamide inhibitors of cytosolic group IVA phospholipase A(2) with reduced lipophilicity

Por Antonopoulou, Georgia, Magrioti, Victoria, Kokotou, Maroula G., Nikolaou, Aikaterini, Barbayianni, Efrosini, Mouchlis, Varnavas D., Dennis, Edward A., Kokotos, George
Publicado no Bioorg Med Chem (2016)

Inhibition of secreted phospholipases A(2) by 2-oxoamides based on α-amino acids: Synthesis, in vitro evaluation and molecular docking calculations

Por Mouchlis, Varnavas D., Magrioti, Victoria, Barbayianni, Efrosini, Cermak, Nathan, Oslund, Rob C., Mavromoustakos, Thomas M., Gelb, Michael H., Kokotos, George
Publicado em 2010

Intracellular phospholipase A(2) group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury

Por López-Vales, Rubèn, Navarro, Xavier, Shimizu, Takao, Baskakis, Constantinos, Kokotos, George, Constantinou-Kokotou, Violetta, Stephens, Daren, Dennis, Edward A., David, Samuel
Publicado em 2008

Inhibition of Ca(2+)-Independent Phospholipase A(2)β (iPLA(2)β) Ameliorates Islet Infiltration and Incidence of Diabetes in NOD Mice

Por Bone, Robert N., Gai, Ying, Magrioti, Victoria, Kokotou, Maroula G., Ali, Tomader, Lei, Xiaoyong, Tse, Hubert M., Kokotos, George, Ramanadham, Sasanka
Publicado no Diabetes (2015)

2-Oxoamide inhibitors of phospholipase A(2) activity and cellular arachidonate release based on dipeptides and pseudodipeptides

Por Barbayianni, Efrosini, Stephens, Daren, Grkovich, Andrej, Magrioti, Victoria, Hsu, Yuan-Hao, Cotton, Naomi, Dolatzas, Panagiotis, Kalogiannidis, Dimitrios, Dennis, Edward A., Kokotos, George
Publicado em 2009

Inhibitor Binding of Group IVA Phospholipase A(2) Probed by Molecular Dynamics and Deuterium Exchange Mass Spectrometry

Por Burke, John E., Babakhani, Arneh, Gorfe, Alemayehu A., Kokotos, George, Li, Sheng, Woods, Virgil L., McCammon, J. Andrew, Dennis, Edward A.
Publicado em 2009

Differential Inhibition of Group IVA and Group VIA Phospholipases A(2) by 2-Oxoamides

Por Stephens, Daren, Barbayianni, Efrosini, Constantinou-Kokotou, Violetta, Peristeraki, Anna, Six, David A., Cooper, Jennifer, Harkewicz, Richard, Deems, Raymond A., Dennis, Edward A., Kokotos, George
Publicado em 2006

Fluoroketone Inhibition of Ca(2+)-Independent Phospholipase A(2) through Binding Pocket Association Defined by Hydrogen/Deuterium Exchange and Molecular Dynamics

Por Hsu, Yuan-Hao, Bucher, Denis, Cao, Jian, Li, Sheng, Yang, Sheng-Wei, Kokotos, George, Woods, Virgil L., McCammon, J. Andrew, Dennis, Edward A.
Publicado em 2012