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A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activity
A variety of long chain 1,2-diamines and related compounds were synthesized and tested for their activity on fatty acid amide hydrolase (FAAH) and monoacyglycerol lipase (MGL). (2S,9Z)-Octadec-9-ene-1,2-diamine selectively inhibits MGL (K(i) 21.8 μM) without significantly affecting FAAH. This compou...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3712614/ https://ncbi.nlm.nih.gov/pubmed/18819796 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.09.039 |
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