A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activity

A variety of long chain 1,2-diamines and related compounds were synthesized and tested for their activity on fatty acid amide hydrolase (FAAH) and monoacyglycerol lipase (MGL). (2S,9Z)-Octadec-9-ene-1,2-diamine selectively inhibits MGL (K(i) 21.8 μM) without significantly affecting FAAH. This compou...

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Detaylı Bibliyografya
Asıl Yazarlar: Magrioti, Victoria, Naxakis, George, Hadjipavlou-Litina, Dimitra, Makriyannis, Alexandros, Kokotos, George
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2008
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712614/
https://ncbi.nlm.nih.gov/pubmed/18819796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.09.039
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