2-Oxoamide inhibitors of cytosolic group IVA phospholipase A(2) with reduced lipophilicity

Cytosolic GIVA phospholipase A(2) (GIVA cPLA(2)) initiates the eicosanoid pathway of inflammation and thus inhibitors of this enzyme constitute novel potential agents for the treatment of inflammatory diseases. Traditionally, GIVA cPLA(2) inhibitors have suffered systemically from high lipophilicity...

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Foilsithe in:Bioorg Med Chem
Main Authors: Antonopoulou, Georgia, Magrioti, Victoria, Kokotou, Maroula G., Nikolaou, Aikaterini, Barbayianni, Efrosini, Mouchlis, Varnavas D., Dennis, Edward A., Kokotos, George
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014611/
https://ncbi.nlm.nih.gov/pubmed/27522578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.07.057
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