2-Oxoamide inhibitors of cytosolic group IVA phospholipase A(2) with reduced lipophilicity

Cytosolic GIVA phospholipase A(2) (GIVA cPLA(2)) initiates the eicosanoid pathway of inflammation and thus inhibitors of this enzyme constitute novel potential agents for the treatment of inflammatory diseases. Traditionally, GIVA cPLA(2) inhibitors have suffered systemically from high lipophilicity...

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Vydáno v:Bioorg Med Chem
Hlavní autoři: Antonopoulou, Georgia, Magrioti, Victoria, Kokotou, Maroula G., Nikolaou, Aikaterini, Barbayianni, Efrosini, Mouchlis, Varnavas D., Dennis, Edward A., Kokotos, George
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014611/
https://ncbi.nlm.nih.gov/pubmed/27522578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.07.057
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