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2-Oxoamide inhibitors of cytosolic group IVA phospholipase A(2) with reduced lipophilicity
Cytosolic GIVA phospholipase A(2) (GIVA cPLA(2)) initiates the eicosanoid pathway of inflammation and thus inhibitors of this enzyme constitute novel potential agents for the treatment of inflammatory diseases. Traditionally, GIVA cPLA(2) inhibitors have suffered systemically from high lipophilicity...
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| Опубликовано в: : | Bioorg Med Chem |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5014611/ https://ncbi.nlm.nih.gov/pubmed/27522578 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.07.057 |
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