2-Oxoamide inhibitors of cytosolic group IVA phospholipase A(2) with reduced lipophilicity

Cytosolic GIVA phospholipase A(2) (GIVA cPLA(2)) initiates the eicosanoid pathway of inflammation and thus inhibitors of this enzyme constitute novel potential agents for the treatment of inflammatory diseases. Traditionally, GIVA cPLA(2) inhibitors have suffered systemically from high lipophilicity...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Bioorg Med Chem
Egile Nagusiak: Antonopoulou, Georgia, Magrioti, Victoria, Kokotou, Maroula G., Nikolaou, Aikaterini, Barbayianni, Efrosini, Mouchlis, Varnavas D., Dennis, Edward A., Kokotos, George
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014611/
https://ncbi.nlm.nih.gov/pubmed/27522578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.07.057
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