2-Oxoamides based on dipeptides as selective calcium-independent phospholipase A(2) inhibitors

Calcium-independent phospholipase A(2) (GVIA iPLA(2)) has recently attracted interest as a medicinal target. The number of known GVIA iPLA(2) inhibitors is limited to a handful of synthetic compounds (bromoenol lactone and polyfluoroketones). To expand the chemical diversity, a variety of 2-oxoamide...

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Publicado en:Bioorg Med Chem
Autores principales: Smyrniotou, Anneta, Kokotou, Maroula G., Mouchlis, Varnavas D., Barbayianni, Efrosini, Kokotos, George, Dennis, Edward A., Constantinou-Kokotou, Violetta
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5291822/
https://ncbi.nlm.nih.gov/pubmed/28034646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.12.007
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