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Development of Potent and Selective Inhibitors for Group VIA Calcium-Independent Phospholipase A(2) Guided by Molecular Dynamics and Structure-Activity Relationships

The development of inhibitors for phospholipases A(2) (PLA(2)s) is important in elucidating their implication in various biological pathways. PLA(2) enzymes are an important pharmacological target implicated in various inflammatory diseases. Computational chemistry, organic synthesis and in vitro as...

詳細記述

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書誌詳細
出版年:J Med Chem
主要な著者: Mouchlis, Varnavas D., Limnios, Dimitris, Kokotou, Maroula G., Barbayianni, Efrosini, Kokotos, George, McCammon, J. Andrew, Dennis, Edward A.
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946799/
https://ncbi.nlm.nih.gov/pubmed/27087127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00377
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