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Development of Potent and Selective Inhibitors for Group VIA Calcium-Independent Phospholipase A(2) Guided by Molecular Dynamics and Structure-Activity Relationships

The development of inhibitors for phospholipases A(2) (PLA(2)s) is important in elucidating their implication in various biological pathways. PLA(2) enzymes are an important pharmacological target implicated in various inflammatory diseases. Computational chemistry, organic synthesis and in vitro as...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Mouchlis, Varnavas D., Limnios, Dimitris, Kokotou, Maroula G., Barbayianni, Efrosini, Kokotos, George, McCammon, J. Andrew, Dennis, Edward A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946799/
https://ncbi.nlm.nih.gov/pubmed/27087127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00377
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