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Development of Potent and Selective Inhibitors for Group VIA Calcium-Independent Phospholipase A(2) Guided by Molecular Dynamics and Structure-Activity Relationships
The development of inhibitors for phospholipases A(2) (PLA(2)s) is important in elucidating their implication in various biological pathways. PLA(2) enzymes are an important pharmacological target implicated in various inflammatory diseases. Computational chemistry, organic synthesis and in vitro as...
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| Yayımlandı: | J Med Chem |
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| Asıl Yazarlar: | , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2016
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4946799/ https://ncbi.nlm.nih.gov/pubmed/27087127 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00377 |
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