Development of Potent and Selective Inhibitors for Group VIA Calcium-Independent Phospholipase A(2) Guided by Molecular Dynamics and Structure-Activity Relationships

The development of inhibitors for phospholipases A(2) (PLA(2)s) is important in elucidating their implication in various biological pathways. PLA(2) enzymes are an important pharmacological target implicated in various inflammatory diseases. Computational chemistry, organic synthesis and in vitro as...

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Bibliographic Details
Published in:J Med Chem
Main Authors: Mouchlis, Varnavas D., Limnios, Dimitris, Kokotou, Maroula G., Barbayianni, Efrosini, Kokotos, George, McCammon, J. Andrew, Dennis, Edward A.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946799/
https://ncbi.nlm.nih.gov/pubmed/27087127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00377
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