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Binding Conformation of 2-Oxoamide Inhibitors to Group IVA Cytosolic Phospholipase A(2) Determined by Molecular Docking Combined with Molecular Dynamics

The Group IVA cytosolic phospholipase A(2) (GIVA cPLA(2)) plays a central role in inflammation. Long chain 2-oxoamides constitute a class of potent GIVA cPLA(2) inhibitors that exhibit potent in vivo anti-inflammatory and analgesic activity. We have now gained insight into the binding of 2-oxoamide...

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Main Authors: Mouchlis, Varnavas D., Michopoulou, Vasiliki, Constantinou-Kokotou, Violetta, Mavromoustakos, Thomas, Dennis, Edward A., Kokotos, George
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265118/
https://ncbi.nlm.nih.gov/pubmed/22196172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci2005093
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