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Binding Conformation of 2-Oxoamide Inhibitors to Group IVA Cytosolic Phospholipase A(2) Determined by Molecular Docking Combined with Molecular Dynamics
The Group IVA cytosolic phospholipase A(2) (GIVA cPLA(2)) plays a central role in inflammation. Long chain 2-oxoamides constitute a class of potent GIVA cPLA(2) inhibitors that exhibit potent in vivo anti-inflammatory and analgesic activity. We have now gained insight into the binding of 2-oxoamide...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3265118/ https://ncbi.nlm.nih.gov/pubmed/22196172 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci2005093 |
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