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Synthesis of 2-oxoamides based on sulfonamide analogues of γ-amino acids and their activity on phospholipase A(2)

A variety of lipophilic 2-oxoamides containing sulfonamide analogues of γ-amino acids as well as acyl sulfonamides of γ-aminobutyric acid were synthesized. Their ability to inhibit intracellular GIVA cPLA(2) and GVIA iPLA(2) as well as secreted GV sPLA(2) was evaluated. The sulfonamide group seems a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Antonopoulou, Georgia, Magrioti, Victoria, Stephens, Daren, Constantinou-Kokotou, Violetta, Dennis, Edward A., Kokotos, George
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2678953/
https://ncbi.nlm.nih.gov/pubmed/18618424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psc.1048
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