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Synthesis of 2-oxoamides based on sulfonamide analogues of γ-amino acids and their activity on phospholipase A(2)

A variety of lipophilic 2-oxoamides containing sulfonamide analogues of γ-amino acids as well as acyl sulfonamides of γ-aminobutyric acid were synthesized. Their ability to inhibit intracellular GIVA cPLA(2) and GVIA iPLA(2) as well as secreted GV sPLA(2) was evaluated. The sulfonamide group seems a...

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Detalles Bibliográficos
Main Authors: Antonopoulou, Georgia, Magrioti, Victoria, Stephens, Daren, Constantinou-Kokotou, Violetta, Dennis, Edward A., Kokotos, George
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2678953/
https://ncbi.nlm.nih.gov/pubmed/18618424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psc.1048
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