Differential Inhibition of Group IVA and Group VIA Phospholipases A(2) by 2-Oxoamides

Inhibitors of the Group IVA phospholipase A(2) (GIVA cPLA(2)) and GVIA iPLA(2) are useful tools for defining the roles of these enzymes in cellular signaling and inflammation. We have developed inhibitors of GVIA iPLA(2) based on the 2-oxoamide backbone that are uncharged, containing ester groups. W...

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Autores principales: Stephens, Daren, Barbayianni, Efrosini, Constantinou-Kokotou, Violetta, Peristeraki, Anna, Six, David A., Cooper, Jennifer, Harkewicz, Richard, Deems, Raymond A., Dennis, Edward A., Kokotos, George
Formato: Artigo
Lenguaje:Inglês
Publicado: 2006
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2544624/
https://ncbi.nlm.nih.gov/pubmed/16640343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm050993h
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