Synthesis of Polyfluoro Ketones for Selective Inhibition of Human Phospholipase A(2) Enzymes

The development of selective inhibitors for individual PLA(2) enzymes is necessary in order to target PLA(2)-specific signaling pathways; but it is challenging due to the observed promiscuity of known PLA(2) inhibitors. In the current work, we present the development and application of a variety of...

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Hauptverfasser: Baskakis, Constantinos, Magrioti, Victoria, Cotton, Naomi, Stephens, Daren, Constantinou-Kokotou, Violetta, Dennis, Edward A., Kokotos, George
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649009/
https://ncbi.nlm.nih.gov/pubmed/19053783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800649q
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