Characterization of FKGK18 as Inhibitor of Group VIA Ca(2+)-Independent Phospholipase A(2) (iPLA(2)β): Candidate Drug for Preventing Beta-Cell Apoptosis and Diabetes

Ongoing studies suggest an important role for iPLA(2)β in a multitude of biological processes and it has been implicated in neurodegenerative, skeletal and vascular smooth muscle disorders, bone formation, and cardiac arrhythmias. Thus, identifying an iPLA(2)βinhibitor that can be reliably and safel...

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Hlavní autoři: Ali, Tomader, Kokotos, George, Magrioti, Victoria, Bone, Robert N., Mobley, James A., Hancock, William, Ramanadham, Sasanka
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748103/
https://ncbi.nlm.nih.gov/pubmed/23977134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071748
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