Inhibition of Ca(2+)-Independent Phospholipase A(2)β (iPLA(2)β) Ameliorates Islet Infiltration and Incidence of Diabetes in NOD Mice

Autoimmune β-cell death leads to type 1 diabetes, and with findings that Ca(2+)-independent phospholipase A(2)β (iPLA(2)β) activation contributes to β-cell death, we assessed the effects of iPLA(2)β inhibition on diabetes development. Administration of FKGK18, a reversible iPLA(2)β inhibitor, to NOD...

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Publicado en:Diabetes
Main Authors: Bone, Robert N., Gai, Ying, Magrioti, Victoria, Kokotou, Maroula G., Ali, Tomader, Lei, Xiaoyong, Tse, Hubert M., Kokotos, George, Ramanadham, Sasanka
Formato: Artigo
Idioma:Inglês
Publicado: American Diabetes Association 2015
Assuntos:
Islet Studies
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303959/
https://ncbi.nlm.nih.gov/pubmed/25213337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-0097
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