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Inhibition of Ca(2+)-Independent Phospholipase A(2)β (iPLA(2)β) Ameliorates Islet Infiltration and Incidence of Diabetes in NOD Mice
Autoimmune β-cell death leads to type 1 diabetes, and with findings that Ca(2+)-independent phospholipase A(2)β (iPLA(2)β) activation contributes to β-cell death, we assessed the effects of iPLA(2)β inhibition on diabetes development. Administration of FKGK18, a reversible iPLA(2)β inhibitor, to NOD...
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| Pubblicato in: | Diabetes |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Diabetes Association
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4303959/ https://ncbi.nlm.nih.gov/pubmed/25213337 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-0097 |
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