Characterization of FKGK18 as Inhibitor of Group VIA Ca(2+)-Independent Phospholipase A(2) (iPLA(2)β): Candidate Drug for Preventing Beta-Cell Apoptosis and Diabetes

Ongoing studies suggest an important role for iPLA(2)β in a multitude of biological processes and it has been implicated in neurodegenerative, skeletal and vascular smooth muscle disorders, bone formation, and cardiac arrhythmias. Thus, identifying an iPLA(2)βinhibitor that can be reliably and safel...

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Detalhes bibliográficos
Main Authors: Ali, Tomader, Kokotos, George, Magrioti, Victoria, Bone, Robert N., Mobley, James A., Hancock, William, Ramanadham, Sasanka
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748103/
https://ncbi.nlm.nih.gov/pubmed/23977134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071748
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