2-Oxoamide inhibitors of phospholipase A(2) activity and cellular arachidonate release based on dipeptides and pseudodipeptides

A series of 2-oxoamides based on dipeptides and pseudodipeptides were synthesized and their activities toward two human intracellular phospholipases A(2) (GIVA cPLA(2) and GVIA iPLA(2)) and one human secretory phospholipase A(2) (GV sPLA(2)) were evaluated. Derivatives containing a free carboxyl gro...

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Detalhes bibliográficos
Main Authors: Barbayianni, Efrosini, Stephens, Daren, Grkovich, Andrej, Magrioti, Victoria, Hsu, Yuan-Hao, Cotton, Naomi, Dolatzas, Panagiotis, Kalogiannidis, Dimitrios, Dennis, Edward A., Kokotos, George
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695835/
https://ncbi.nlm.nih.gov/pubmed/19443224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.03.069
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