2-Oxoamide inhibitors of phospholipase A(2) activity and cellular arachidonate release based on dipeptides and pseudodipeptides

A series of 2-oxoamides based on dipeptides and pseudodipeptides were synthesized and their activities toward two human intracellular phospholipases A(2) (GIVA cPLA(2) and GVIA iPLA(2)) and one human secretory phospholipase A(2) (GV sPLA(2)) were evaluated. Derivatives containing a free carboxyl gro...

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Opis bibliograficzny
Główni autorzy: Barbayianni, Efrosini, Stephens, Daren, Grkovich, Andrej, Magrioti, Victoria, Hsu, Yuan-Hao, Cotton, Naomi, Dolatzas, Panagiotis, Kalogiannidis, Dimitrios, Dennis, Edward A., Kokotos, George
Format: Artigo
Język:Inglês
Wydane: 2009
Hasła przedmiotowe:
Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695835/
https://ncbi.nlm.nih.gov/pubmed/19443224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.03.069
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