2-Oxoamide inhibitors of phospholipase A(2) activity and cellular arachidonate release based on dipeptides and pseudodipeptides

A series of 2-oxoamides based on dipeptides and pseudodipeptides were synthesized and their activities toward two human intracellular phospholipases A(2) (GIVA cPLA(2) and GVIA iPLA(2)) and one human secretory phospholipase A(2) (GV sPLA(2)) were evaluated. Derivatives containing a free carboxyl gro...

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Bibliografski detalji
Glavni autori: Barbayianni, Efrosini, Stephens, Daren, Grkovich, Andrej, Magrioti, Victoria, Hsu, Yuan-Hao, Cotton, Naomi, Dolatzas, Panagiotis, Kalogiannidis, Dimitrios, Dennis, Edward A., Kokotos, George
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695835/
https://ncbi.nlm.nih.gov/pubmed/19443224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.03.069
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