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Development of a potent 2-oxoamide inhibitor of secreted phospholipase A(2) guided by molecular docking calculations and molecular dynamics simulations
Inhibition of group IIA secreted phospholipase A(2) (GIIA sPLA(2)) has been an important objective for medicinal chemists. We have previously shown that inhibitors incorporating the 2-oxoamide functionality may inhibit human and mouse GIIA sPLA(2)s. Herein, the development of new potent inhibitors b...
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| Publicado no: | Bioorg Med Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5292099/ https://ncbi.nlm.nih.gov/pubmed/26970660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.02.040 |
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