Development of a potent 2-oxoamide inhibitor of secreted phospholipase A(2) guided by molecular docking calculations and molecular dynamics simulations

Inhibition of group IIA secreted phospholipase A(2) (GIIA sPLA(2)) has been an important objective for medicinal chemists. We have previously shown that inhibitors incorporating the 2-oxoamide functionality may inhibit human and mouse GIIA sPLA(2)s. Herein, the development of new potent inhibitors b...

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Détails bibliographiques
Publié dans:Bioorg Med Chem
Auteurs principaux: Vasilakaki, Sofia, Barbayianni, Efrosini, Leonis, Georgios, Papadopoulos, Manthos G., Mavromoustakos, Thomas, Gelb, Michael H., Kokotos, George
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5292099/
https://ncbi.nlm.nih.gov/pubmed/26970660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.02.040
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