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Fluoroketone Inhibition of Ca(2+)-Independent Phospholipase A(2) through Binding Pocket Association Defined by Hydrogen/Deuterium Exchange and Molecular Dynamics
[Image: see text] The mechanism of inhibition of group VIA Ca(2+)-independent phospholipase A(2) (iPLA(2)) by fluoroketone (FK) ligands is examined by a combination of deuterium exchange mass spectrometry (DXMS) and molecular dynamics (MD). Models for iPLA(2) were built by homology with the known st...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Chemical Society
2012
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| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3561773/ https://ncbi.nlm.nih.gov/pubmed/23256506 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja306490g |
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