Frequent promoter hypermethylation of PTPRT increases STAT3 activation and sensitivity to STAT3 inhibition in head and neck cancer

Por Peyser, Noah D., Freilino, Maria, Wang, Lin, Zeng, Yan, Li, Hua, Johnson, Daniel E., Grandis, Jennifer R.
Publicado no Oncogene (2015)

Targeting TORC1/2 Enhances Sensitivity to EGFR Inhibitors in Head and Neck Cancer Preclinical Models

Por Cassell, Andre, Freilino, Maria L, Lee, Jessica, Barr, Sharon, Wang, Lin, Panahandeh, Mary C, Thomas, Sufi M, Grandis, Jennifer R
Publicado em 2012

Targeting GPCR-mediated p70S6K activity may improve head and neck cancer response to cetuximab

Por Bhola, Neil E., Thomas, Sufi M., Freilino, Maria, Joyce, Sonali, Sahu, Anirban, Maxwell, Jessica, Argiris, Athanassios, Seethala, Raja, Grandis, Jennifer R.
Publicado em 2011

Serum Biomarker Modulation Following Molecular Targeting of Epidermal Growth Factor and Cycloxygenase Pathways: a Pilot Randomized Trial in Head and Neck Cancer

Por Moskowitz, Howard S., Gooding, William E., Thomas, Sufi M., Freilino, Maria L., Gross, Neil, Argiris, Athanassios, Grandis, Jennifer R., Ferris, Robert L.
Publicado em 2012

Systemic Administration of a Cyclic Signal Transducer and Activator of Transcription 3 (STAT3) Decoy Oligonucleotide Inhibits Tumor Growth without Inducing Toxicological Effects

Por Sen, Malabika, Paul, Kathleen, Freilino, Maria L, Li, Hua, Li, Changyou, Johnson, Daniel E, Wang, Lin, Eiseman, Julie, Grandis, Jennifer R
Publicado em 2013

Combined Targeting of Epidermal Growth Factor Receptor, Signal Transducer and Activator of Transcription-3, and Bcl-X(L) Enhances Antitumor Effects in Squamous Cell Carcinoma of th...

Por Boehm, Amanda L., Sen, Malabika, Seethala, Raja, Gooding, William E., Freilino, Maria, Yan Wong, Silvia Man, Wang, Shaomeng, Johnson, Daniel E., Grandis, Jennifer Rubin
Publicado em 2008

Anti-tumor mechanisms of targeting the PDK1 pathway in head and neck cancer

Por Bhola, Neil E., Freilino, Maria L., Joyce, Sonali C., Sen, Malabika, Thomas, Sufi M., Sahu, Anirban, Cassell, Andre, Chen, Ching-Shih, Grandis, Jennifer R.
Publicado em 2012

Carfilzomib and ONX 0912 Inhibit Cell Survival and Tumor Growth of Head and Neck Cancer and Their Activities are Enhanced by Suppression of Mcl-1 or Autophagy

Por Zang, Yan, Thomas, Sufi M., Chan, Elena T., Kirk, Christopher J., Freilino, Maria L., DeLancey, Hannah M., Grandis, Jennifer R., Li, Changyou, Johnson, Daniel E.
Publicado em 2012

The next generation proteasome inhibitors carfilzomib and oprozomib activate prosurvival autophagy via induction of the unfolded protein response and ATF4

Por Zang, Yan, Thomas, Sufi M., Chan, Elena T., Kirk, Christopher J., Freilino, Maria L., DeLancey, Hannah M., Grandis, Jennifer R., Li, Changyou, Johnson, Daniel E.
Publicado em 2012

Combined Inhibition of c-Src and Epidermal Growth Factor Receptor Abrogates Growth and Invasion of Head and Neck Squamous Cell Carcinoma

Por Koppikar, Priya, Choi, Seung-Ho, Egloff, Ann Marie, Cai, Quan, Suzuki, Shinsuke, Freilino, Maria, Nozawa, Hiroshi, Thomas, Sufi M., Gooding, William E., Siegfried, Jill M., Grandis, Jennifer R.
Publicado em 2008

STAT3 as a chemoprevention target in carcinogen-induced head and neck squamous cell carcinoma

Por Peyser, Noah D., Wang, Lin, Zeng, Yan, Acquafondata, Marie, Freilino, Maria, Li, Hua, Sen, Malabika, Gooding, William E., Satake, Masanobu, Wang, Zhenghe, Johnson, Daniel E., Grandis, Jennifer R.
Publicado no Cancer Prev Res (Phila) (2016)

JAK Kinase Inhibition Abrogates STAT3 Activation and Head and Neck Squamous Cell Carcinoma Tumor Growth()()

Por Sen, Malabika, Pollock, Netanya I., Black, John, DeGrave, Kara A., Wheeler, Sarah, Freilino, Maria L., Joyce, Sonali, Lui, Vivian W.Y., Zeng, Yan, Chiosea, Simion I., Grandis, Jennifer R.
Publicado no Neoplasia (2015)

Mechanism of action of selective inhibitors of IL-6 induced STAT3 pathway in head and neck cancer cell lines

Por Sen, Malabika, Johnston, Paul A., Pollock, Netanya I., DeGrave, Kara, Joyce, Sonali C., Freilino, Maria L., Hua, Yun, Camarco, Daniel P., Close, David A., Huryn, Donna M., Wipf, Peter, Grandis, Jennifer R.
Publicado no J Chem Biol (2017)

Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinoma

Por Leeman-Neill, Rebecca J., Seethala, Raja R., Singh, Shivendra V., Freilino, Maria L., Bednash, Joseph S., Thomas, Sufi M., Panahandeh, Mary C., Gooding, William E., Joyce, Sonali C., Lingen, Mark W., Neill, Daniel B., Grandis, Jennifer R.
Publicado em 2010

Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma

Por Hedberg, Matthew L., Goh, Gerald, Chiosea, Simion I., Bauman, Julie E., Freilino, Maria L., Zeng, Yan, Wang, Lin, Diergaarde, Brenda B., Gooding, William E., Lui, Vivian W.Y., Herbst, Roy S., Lifton, Richard P., Grandis, Jennifer R.
Publicado no J Clin Invest (2015)

Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma

Por Hedberg, Matthew L., Goh, Gerald, Chiosea, Simion I., Bauman, Julie E., Freilino, Maria L., Zeng, Yan, Wang, Lin, Diergaarde, Brenda B., Gooding, William E., Lui, Vivian W.Y., Herbst, Roy S., Lifton, Richard P., Grandis, Jennifer R.
Publicado no J Clin Invest (2016)

Guggulsterone enhances head and neck cancer therapies via inhibition of signal transducer and activator of transcription-3

Por Leeman-Neill, Rebecca J., Wheeler, Sarah E., Singh, Shivendra V., Thomas, Sufi M., Seethala, Raja R., Neill, Daniel B., Panahandeh, Mary C., Hahm, Eun-Ryeong, Joyce, Sonali C., Sen, Malabika, Cai, Quan, Freilino, Maria L., Li, Changyou, Johnson, Daniel E., Grandis, Jennifer R.
Publicado em 2009

First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy

Por Sen, Malabika, Thomas, Sufi. M., Kim, Seungwon, Yeh, Joanne I., Ferris, Robert L., Johnson, Jonas T., Duvvuri, Umamaheswar, Lee, Jessica, Sahu, Nivedita, Joyce, Sonali, Freilino, Maria L., Shi, Haibin, Li, Changyou, Ly, Danith, Rapireddy, Srinivas, Etter, Jonathan P., Li, Pui-Kai, Wang, Lin, Chiosea, Simion, Seethala, Raja R., Gooding, William. E., Chen, Xiaomin, Kaminski, Naftali, Pandit, Kusum, Johnson, Daniel. E., Grandis, Jennifer R.
Publicado em 2012

Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers

Por Lui, Vivian Wai Yan, Hedberg, Matthew L., Li, Hua, Vangara, Bhavana S., Pendleton, Kelsey, Zeng, Yan, Lu, Yiling, Zhang, Qiuhong, Du, Yu, Gilbert, Breean, Freilino, Maria, Sauerwein, Sam, Peyser, Noah, Xiao, Dong, Diergaarde, Brenda, Wang, Lin, Chiosea, Simion, Seethala, Raja, Johnson, Jonas T., Kim, Seungwon, Duvvuri, Umamaheswar, Ferris, Robert L., Romkes, Marjorie, Nukui, Tomoko, Ng, Patrick Kwok-Shing, Garraway, Levi A., Hammerman, Peter S., Mills, Gordon B., Grandis, Jennifer R.
Publicado em 2013