Nucleic acid-based approaches to STAT inhibition

Por Sen, Malabika, Grandis, Jennifer R.
Publicado em 2012

Caspase‐8 mutations in head and neck cancer confer resistance to death receptor‐mediated apoptosis and enhance migration, invasion, and tumor growth

Por Li, Changyou, Egloff, Ann Marie, Sen, Malabika, Grandis, Jennifer R., Johnson, Daniel E.
Publicado em 2014

STAT3 Oligonucleotide Inhibits Tumor Angiogenesis in Preclinical Models of Squamous Cell Carcinoma

Por Klein, Jonah D., Sano, Daisuke, Sen, Malabika, Myers, Jeffrey N., Grandis, Jennifer R., Kim, Seungwon
Publicado em 2014

Bortezomib up-regulates activated signal transducer and activator of transcription-3 and synergizes with inhibitors of signal transducer and activator of transcription-3 to promote...

Por Li, Changyou, Zang, Yan, Sen, Malabika, Leeman-Neill, Rebecca J., Grandis, Jennifer R., Johnson, Daniel E.
Publicado em 2009

High-Content pSTAT3/1 Imaging Assays to Screen for Selective Inhibitors of STAT3 Pathway Activation in Head and Neck Cancer Cell Lines

Por Johnston, Paul A., Sen, Malabika, Hua, Yun, Camarco, Daniel, Shun, Tong Ying, Lazo, John S., Grandis, Jennifer R.
Publicado em 2014

High Content Imaging Assays for IL-6-Induced STAT3 Pathway Activation in Head and Neck Cancer Cell Lines

Por Johnston, Paul A., Sen, Malabika, Hua, Yun, Camarco, Daniel P., Shun, Tong Ying, Lazo, John S., Grandis, Jennifer R.
Publicado no Methods Mol Biol (2018)

Systemic Administration of a Cyclic Signal Transducer and Activator of Transcription 3 (STAT3) Decoy Oligonucleotide Inhibits Tumor Growth without Inducing Toxicological Effects

Por Sen, Malabika, Paul, Kathleen, Freilino, Maria L, Li, Hua, Li, Changyou, Johnson, Daniel E, Wang, Lin, Eiseman, Julie, Grandis, Jennifer R
Publicado em 2013

Ultrasound Targeted Microbubble Destruction-Mediated Delivery of a Transcription Factor Decoy Inhibits STAT3 Signaling and Tumor Growth

Por Kopechek, Jonathan A., Carson, Andrew R., McTiernan, Charles F., Chen, Xucai, Hasjim, Bima, Lavery, Linda, Sen, Malabika, Grandis, Jennifer R., Villanueva, Flordeliza S.
Publicado no Theranostics (2015)

TARGETING STAT3 ABROGATES EGFR INHIBITOR RESISTANCE IN CANCER

Por Sen, Malabika, Joyce, Sonali, Panahandeh, Mary, Li, Changyou, Thomas, Sufi M., Maxwell, Jessica, Wang, Lin, Gooding, William E., Johnson, Daniel E., Grandis, Jennifer R.
Publicado em 2012

Combined Targeting of Epidermal Growth Factor Receptor, Signal Transducer and Activator of Transcription-3, and Bcl-X(L) Enhances Antitumor Effects in Squamous Cell Carcinoma of th...

Por Boehm, Amanda L., Sen, Malabika, Seethala, Raja, Gooding, William E., Freilino, Maria, Yan Wong, Silvia Man, Wang, Shaomeng, Johnson, Daniel E., Grandis, Jennifer Rubin
Publicado em 2008

Anti-tumor mechanisms of targeting the PDK1 pathway in head and neck cancer

Por Bhola, Neil E., Freilino, Maria L., Joyce, Sonali C., Sen, Malabika, Thomas, Sufi M., Sahu, Anirban, Cassell, Andre, Chen, Ching-Shih, Grandis, Jennifer R.
Publicado em 2012

Utility of 3’-[(18)F]fluoro-3’-deoxythymidine as a PET tracer to monitor response to gene therapy in a xenograft model of head and neck carcinoma

Por Mason, Neale S, Lopresti, Brian J, Ruszkiewicz, James, Dong, Xinxin, Joyce, Sonali, Leef, George, Sen, Malabika, Wahed, Abdus S, Mathis, Chester A, Grandis, Jennifer R, Thomas, Sufi M
Publicado em 2013

TOXICITY, PHARMACOKINETICS AND METABOLISM OF A NOVEL INHIBITOR OF IL-6-INDUCED STAT3 ACTIVATION

Por Kiesel, Brian F., Parise, Robert A., Guo, Jianxia, Huryn, Donna M., Johnston, Paul A., Colombo, Raffaele, Sen, Malabika, Grandis, Jennifer R., Beumer, Jan H., Eiseman, Julie L.
Publicado no Cancer Chemother Pharmacol (2016)

Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation

Por Suzuki, Shinsuke, Morgan, Sarah E., Thomas, Sufi M., Sen, Malabika, Leeman-Neill, Rebecca J., Kuan, Chien-Tsun, Bigner, Darrell, Gooding, William E., Lai, Stephen Y., Grandis, Jennifer R.
Publicado em 2010

INCREASED EXPRESSION OF HER2, HER3 and HER2:HER3 HETERODIMERS IN HPV-POSITIVE HNSCC USING A NOVEL PROXIMITY-BASED ASSAY: IMPLICATIONS FOR TARGETED THERAPIES

Por Pollock, Netanya I., Wang, Lin, Wallweber, Gerald, Gooding, William E, Huang, Weidong, Chenna, Ahmed, Winslow, John, Sen, Malabika, DeGrave, Kara, Li, Hua, Zeng, Y, Grandis, Jennifer R.
Publicado no Clin Cancer Res (2015)

STAT3 as a chemoprevention target in carcinogen-induced head and neck squamous cell carcinoma

Por Peyser, Noah D., Wang, Lin, Zeng, Yan, Acquafondata, Marie, Freilino, Maria, Li, Hua, Sen, Malabika, Gooding, William E., Satake, Masanobu, Wang, Zhenghe, Johnson, Daniel E., Grandis, Jennifer R.
Publicado no Cancer Prev Res (Phila) (2016)

Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane

Por Bauman, Julie E., Zang, Yan, Sen, Malabika, Li, Changyou, Wang, Lin, Egner, Patricia A., Fahey, Jed W., Normolle, Daniel P., Grandis, Jennifer R., Kensler, Thomas W., Johnson, Daniel E.
Publicado no Cancer Prev Res (Phila) (2016)

JAK Kinase Inhibition Abrogates STAT3 Activation and Head and Neck Squamous Cell Carcinoma Tumor Growth()()

Por Sen, Malabika, Pollock, Netanya I., Black, John, DeGrave, Kara A., Wheeler, Sarah, Freilino, Maria L., Joyce, Sonali, Lui, Vivian W.Y., Zeng, Yan, Chiosea, Simion I., Grandis, Jennifer R.
Publicado no Neoplasia (2015)

Phase 1 Study of EGFR-Antisense DNA, Cetuximab, and Radiotherapy in Head and Neck Cancer With Preclinical Correlatives

Por Bauman, Julie E., Duvvuri, Umamaheswar, Thomas, Sufi, Gooding, William E., Clump, David A., Karlovits, Brian, Wehbe, Ahmad, Miller, Frank R., Kim, Seungwon, Sen, Malabika, Heron, Dwight E., Grandis, Jennifer R., Argiris, Athanassios
Publicado no Cancer (2018)

2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway

Por LaPorte, Matthew G., da Paz Lima, Dimas José, Zhang, Feng, Sen, Malabika, Grandis, Jennifer R., Camarco, Daniel, Hua, Yun, Johnston, Paul A., Lazo, John S., Resnick, Lynn O., Wipf, Peter, Huryn, Donna M.
Publicado no Bioorg Med Chem Lett (2014)