Systemic Administration of a Cyclic Signal Transducer and Activator of Transcription 3 (STAT3) Decoy Oligonucleotide Inhibits Tumor Growth without Inducing Toxicological Effects

Hyperactivation of signal transducer and activator of transcription 3 (STAT3) has been linked to tumorigenesis in most malignancies, including head and neck squamous cell carcinoma. Intravenous delivery of a chemically modified cyclic STAT3 decoy oligonucleotide with improved serum and thermal stabi...

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Detalhes bibliográficos
Main Authors: Sen, Malabika, Paul, Kathleen, Freilino, Maria L, Li, Hua, Li, Changyou, Johnson, Daniel E, Wang, Lin, Eiseman, Julie, Grandis, Jennifer R
Formato: Artigo
Idioma:Inglês
Publicado em: ScholarOne 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951464/
https://ncbi.nlm.nih.gov/pubmed/24395569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2013.00104
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