First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy

Despite evidence implicating transcription factors, including STAT3, in oncogenesis, these proteins have been regarded as “undruggable”. We developed a decoy targeting STAT3 and performed a phase 0 trial. Expression levels of STAT3 target genes were decreased in the head and neck cancers following i...

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Autors principals: Sen, Malabika, Thomas, Sufi. M., Kim, Seungwon, Yeh, Joanne I., Ferris, Robert L., Johnson, Jonas T., Duvvuri, Umamaheswar, Lee, Jessica, Sahu, Nivedita, Joyce, Sonali, Freilino, Maria L., Shi, Haibin, Li, Changyou, Ly, Danith, Rapireddy, Srinivas, Etter, Jonathan P., Li, Pui-Kai, Wang, Lin, Chiosea, Simion, Seethala, Raja R., Gooding, William. E., Chen, Xiaomin, Kaminski, Naftali, Pandit, Kusum, Johnson, Daniel. E., Grandis, Jennifer R.
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668699/
https://ncbi.nlm.nih.gov/pubmed/22719020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-12-0191
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