First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy

Despite evidence implicating transcription factors, including STAT3, in oncogenesis, these proteins have been regarded as “undruggable”. We developed a decoy targeting STAT3 and performed a phase 0 trial. Expression levels of STAT3 target genes were decreased in the head and neck cancers following i...

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Bibliografski detalji
Glavni autori: Sen, Malabika, Thomas, Sufi. M., Kim, Seungwon, Yeh, Joanne I., Ferris, Robert L., Johnson, Jonas T., Duvvuri, Umamaheswar, Lee, Jessica, Sahu, Nivedita, Joyce, Sonali, Freilino, Maria L., Shi, Haibin, Li, Changyou, Ly, Danith, Rapireddy, Srinivas, Etter, Jonathan P., Li, Pui-Kai, Wang, Lin, Chiosea, Simion, Seethala, Raja R., Gooding, William. E., Chen, Xiaomin, Kaminski, Naftali, Pandit, Kusum, Johnson, Daniel. E., Grandis, Jennifer R.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668699/
https://ncbi.nlm.nih.gov/pubmed/22719020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-12-0191
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