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2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway
Synthesis and SAR investigation of 2-guanidinoquinazolines, initially identified in a high content screen for selective STAT3 pathway inhibitors, led to a more potent analog (11c) that demonstrated improved anti-proliferative activity against a panel of HNSCC cell lines.
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4250329/ https://ncbi.nlm.nih.gov/pubmed/25288188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.09.001 |
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