HGF/Met Signaling in Head and Neck Cancer: Impact on the Tumor Microenvironment

par Hartmann, Stefan, Bhola, Neil E., Grandis, Jennifer R.
Publié dans Clin Cancer Res (2016)

A sensible approach to targeting STAT3-mediated transcription

par Bhola, Neil E., Johnson, Daniel E., Grandis, Jennifer R.
Publié dans Ann Transl Med (2016)

Interleukin 6 is increased in preclinical HNSCC models of acquired cetuximab resistance, but is not required for maintenance of resistance

par O’Keefe, Rachel A., Bhola, Neil E., Lee, David S., Johnson, Daniel E., Grandis, Jennifer R.
Publié dans PLoS One (2020)

Trastuzumab-resistant cells rely on a HER2-PI3K-FoxO-survivin axis and are sensitive to PI3K inhibitors

par Chakrabarty, Anindita, Bhola, Neil E., Sutton, Cammie, Ghosh, Ritwik, Kuba, María Gabriela, Dave, Bhuvanesh, Chang, Jenny C., Arteaga, Carlos L.
Publié 2012

Targeting GPCR-mediated p70S6K activity may improve head and neck cancer response to cetuximab

par Bhola, Neil E., Thomas, Sufi M., Freilino, Maria, Joyce, Sonali, Sahu, Anirban, Maxwell, Jessica, Argiris, Athanassios, Seethala, Raja, Grandis, Jennifer R.
Publié 2011

Small molecule inhibitor of the bone morphogenetic protein pathway DMH1 reduces ovarian cancer cell growth

par Hover, Laura D., Young, Christian D., Bhola, Neil E., Wilson, Andrew J., Khabele, Dineo, Hong, Charles C., Moses, Harold L., Owens, Philip
Publié dans Cancer Lett (2015)

Treatment of Triple Negative Breast Cancer With TORC1/2 Inhibitors Sustains a Drug-resistant and Notch-dependent Cancer Stem Cell Population

par Bhola, Neil E., Jansen, Valerie M., Koch, James P., Li, Hua, Formisano, Luigi, Williams, Janice A., Grandis, Jennifer R., Arteaga, Carlos L.
Publié dans Cancer Res (2015)

TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer

par Bhola, Neil E., Balko, Justin M., Dugger, Teresa C., Kuba, María Gabriela, Sánchez, Violeta, Sanders, Melinda, Stanford, Jamie, Cook, Rebecca S., Arteaga, Carlos L.
Publié 2013

Activation of MAPK pathways due to DUSP4 loss promotes cancer stem cell-like phenotypes in basal-like breast cancer

par Balko, Justin M., Schwarz, Luis J., Bhola, Neil E., Kurupi, Richard, Owens, Phillip, Miller, Todd W., Gómez, Henry, Cook, Rebecca S., Arteaga, Carlos L.
Publié 2013

ATR inhibition sensitizes HPV(−) and HPV(+) head and neck squamous cell carcinoma to cisplatin

par Leonard, Brandon C., Lee, Eliot D., Bhola, Neil E., Li, Hua, Sogaard, Kristian K., Bakkenist, Christopher J., Grandis, Jennifer R., Johnson, Daniel E.
Publié dans Oral Oncol (2019)

Honokiol inhibits EGFR signaling and enhances the antitumor effects of EGFR inhibitors

par Leeman-Neill, Rebecca J., Cai, Quan, Joyce, Sonali C., Thomas, Sufi M., Bhola, Neil E., Neill, Daniel B., Arbiser, Jack L., Grandis, Jennifer R.
Publié 2010

Anti-tumor mechanisms of targeting the PDK1 pathway in head and neck cancer

par Bhola, Neil E., Freilino, Maria L., Joyce, Sonali C., Sen, Malabika, Thomas, Sufi M., Sahu, Anirban, Cassell, Andre, Chen, Ching-Shih, Grandis, Jennifer R.
Publié 2012

BET inhibition overcomes receptor tyrosine kinase-mediated cetuximab resistance in HNSCC

par Leonard, Brandon, Brand, Toni M, O’Keefe, Rachel A, Lee, Eliot D, Zeng, Yan, Kemmer, Jacquelyn D, Li, Hua, Grandis, Jennifer R, Bhola, Neil E
Publié dans Cancer Res (2018)

Human papillomavirus regulates HER3 expression in head and neck cancer: implications for targeted HER3 therapy in HPV(+) patients

par Brand, Toni M., Hartmann, Stefan, Bhola, Neil E., Peyser, Noah D., Li, Hua, Zeng, Yan, Wechsler, Erin Isaacson, Ranall, Max V., Bandyopadhyay, Sourav, Duvvuri, Umamaheswar, LaVallee, Theresa M., Jordan, Richard C.K., Johnson, Daniel E., Grandis, Jennifer R.
Publié dans Clin Cancer Res (2016)

Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer

par Brand, Toni M., Hartmann, Stefan, Bhola, Neil E., Li, Hua, Zeng, Yan, O’Keefe, Rachel A., Ranall, Max V., Bandyopadhyay, Sourav, Soucheray, Margaret, Krogan, Nevan J., Kemp, Carolyn, Duvvuri, Umamaheswar, LaVallee, Theresa, Johnson, Daniel E., Ozbun, Michelle A., Bauman, Julie E., Grandis, Jennifer R.
Publié dans Cancer Res (2018)

Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance

par Balko, Justin M, Cook, Rebecca S, Vaught, David B, Kuba, María G, Miller, Todd W, Bhola, Neil E, Sanders, Melinda E, Granja-Ingram, Nara M, Smith, J Joshua, Meszoely, Ingrid M, Salter, Janine, Dowsett, Mitch, Stemke-Hale, Katherine, González-Angulo, Ana M, Mills, Gordon B, Pinto, Joseph A, Gómez, Henry L, Arteaga, Carlos L
Publié 2012

Kinome-wide RNA interference screen reveals a role for PDK1 in acquired resistance to CDK4/6 inhibition in ER-positive breast cancer

par Jansen, Valerie M., Bhola, Neil E., Bauer, Joshua A., Formisano, Luigi, Lee, Kyung-min, Hutchinson, Katherine E., Witkiewicz, Agnieszka K., Moore, Preston D., Estrada, Mónica Valéria, Sánchez, Violeta, Ericsson, Paula G., Sanders, Melinda E., Pohlmann, Paula R., Pishvaian, Michael J., Riddle, David A., Dugger, Teresa C., Wei, Wenyi, Knudsen, Erik S., Arteaga, Carlos L.
Publié dans Cancer Res (2017)

Association of FGFR1 with ERα maintains ligand-independent ER transcription and mediates resistance to estrogen deprivation in ER+ breast cancer

par Formisano, Luigi, Stauffer, Kimberly M., Young, Christian D., Bhola, Neil E., Guerrero, Angel L., Jansen, Valerie M., Estrada, Mónica Valeria, Hutchinson, Katherine E., Giltnane, Jennifer M., Schwarz, Luis J., Lu, Yao, Balko, Justin M., Deas, Olivier, Cairo, Stefano, Judde, Jean-Gabriel, Mayer, Ingrid A., Sanders, Melinda E., Dugger, Teresa C., Bianco, Roberto, Stricker, Thomas P., Arteaga, Carlos L.
Publié dans Clin Cancer Res (2017)

Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for PIK3CA-altered head and neck cancer

par Hedberg, Matthew L., Peyser, Noah D., Bauman, Julie E., Gooding, William E., Li, Hua, Bhola, Neil E., Zhu, Tian Ran, Zeng, Yan, Brand, Toni M., Kim, Mi-Ok, Jordan, Richard C.K., VandenBerg, Scott, Olivas, Victor, Bivona, Trever G., Chiosea, Simion I., Wang, Lin, Mills, Gordon B., Johnson, Jonas T., Duvvuri, Umamaheswar, Ferris, Robert L., Ha, Patrick, Johnson, Daniel E., Grandis, Jennifer R.
Publié dans J Exp Med (2019)

Activating PIK3CA Mutations Induce an Epidermal Growth Factor Receptor (EGFR)/Extracellular Signal-regulated Kinase (ERK) Paracrine Signaling Axis in Basal-like Breast Cancer

par Young, Christian D., Zimmerman, Lisa J., Hoshino, Daisuke, Formisano, Luigi, Hanker, Ariella B., Gatza, Michael L., Morrison, Meghan M., Moore, Preston D., Whitwell, Corbin A., Dave, Bhuvanesh, Stricker, Thomas, Bhola, Neil E., Silva, Grace O., Patel, Premal, Brantley-Sieders, Dana M., Levin, Maren, Horiates, Marina, Palma, Norma A., Wang, Kai, Stephens, Philip J., Perou, Charles M., Weaver, Alissa M., O'Shaughnessy, Joyce A., Chang, Jenny C., Park, Ben Ho, Liebler, Daniel C., Cook, Rebecca S., Arteaga, Carlos L.
Publié dans Mol Cell Proteomics (2015)