Association of FGFR1 with ERα maintains ligand-independent ER transcription and mediates resistance to estrogen deprivation in ER+ breast cancer

PURPOSE: FGFR1 amplification occurs in ~15% of ER+ human breast cancers.We investigated mechanisms by which FGFR1 amplification confers antiestrogen resistance to ER+ breast cancer. METHODS: ER+ tumors from patients treated with letrozole before surgery were subjected to Ki67 immunohistochemistry, F...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Formisano, Luigi, Stauffer, Kimberly M., Young, Christian D., Bhola, Neil E., Guerrero, Angel L., Jansen, Valerie M., Estrada, Mónica Valeria, Hutchinson, Katherine E., Giltnane, Jennifer M., Schwarz, Luis J., Lu, Yao, Balko, Justin M., Deas, Olivier, Cairo, Stefano, Judde, Jean-Gabriel, Mayer, Ingrid A., Sanders, Melinda E., Dugger, Teresa C., Bianco, Roberto, Stricker, Thomas P., Arteaga, Carlos L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6681458/
https://ncbi.nlm.nih.gov/pubmed/28751448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-1232
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