Association of FGFR1 with ERα maintains ligand-independent ER transcription and mediates resistance to estrogen deprivation in ER+ breast cancer

PURPOSE: FGFR1 amplification occurs in ~15% of ER+ human breast cancers.We investigated mechanisms by which FGFR1 amplification confers antiestrogen resistance to ER+ breast cancer. METHODS: ER+ tumors from patients treated with letrozole before surgery were subjected to Ki67 immunohistochemistry, F...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Clin Cancer Res
Κύριοι συγγραφείς: Formisano, Luigi, Stauffer, Kimberly M., Young, Christian D., Bhola, Neil E., Guerrero, Angel L., Jansen, Valerie M., Estrada, Mónica Valeria, Hutchinson, Katherine E., Giltnane, Jennifer M., Schwarz, Luis J., Lu, Yao, Balko, Justin M., Deas, Olivier, Cairo, Stefano, Judde, Jean-Gabriel, Mayer, Ingrid A., Sanders, Melinda E., Dugger, Teresa C., Bianco, Roberto, Stricker, Thomas P., Arteaga, Carlos L.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2017
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6681458/
https://ncbi.nlm.nih.gov/pubmed/28751448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-1232
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