Association of FGFR1 with ERα maintains ligand-independent ER transcription and mediates resistance to estrogen deprivation in ER+ breast cancer

PURPOSE: FGFR1 amplification occurs in ~15% of ER+ human breast cancers.We investigated mechanisms by which FGFR1 amplification confers antiestrogen resistance to ER+ breast cancer. METHODS: ER+ tumors from patients treated with letrozole before surgery were subjected to Ki67 immunohistochemistry, F...

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Udgivet i:Clin Cancer Res
Main Authors: Formisano, Luigi, Stauffer, Kimberly M., Young, Christian D., Bhola, Neil E., Guerrero, Angel L., Jansen, Valerie M., Estrada, Mónica Valeria, Hutchinson, Katherine E., Giltnane, Jennifer M., Schwarz, Luis J., Lu, Yao, Balko, Justin M., Deas, Olivier, Cairo, Stefano, Judde, Jean-Gabriel, Mayer, Ingrid A., Sanders, Melinda E., Dugger, Teresa C., Bianco, Roberto, Stricker, Thomas P., Arteaga, Carlos L.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6681458/
https://ncbi.nlm.nih.gov/pubmed/28751448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-1232
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