Kinome wide functional screen identifies role of Polo-like kinase 1 (PLK1) in hormone-independent, ER-positive breast cancer

Estrogen receptor α (ER)-positive breast cancers initially respond to antiestrogens but eventually become estrogen-independent and recur. ER+ breast cancer cells resistant to long-term estrogen deprivation (LTED) exhibit hormone-independent ER transcriptional activity and growth. A kinome-wide siRNA...

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Detaylı Bibliyografya
Yayımlandı:Cancer Res
Asıl Yazarlar: Bhola, Neil, Jansen, Valerie M., Bafna, Sangeeta, Giltnane, Jennifer M., Balko, Justin M., Estrada, Mónica V., Meszoely, Ingrid, Mayer, Ingrid, Abramson, Vandana, Ye, Fei, Sanders, Melinda, Dugger, Teresa C., Van Allen, Eliezer, Arteaga, Carlos L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297507/
https://ncbi.nlm.nih.gov/pubmed/25480943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-2475
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