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Kinome-Level Screening Identifies Inhibition of Polo-Like Kinase-1 (PLK1) as a Target for Enhancing Non-Viral Transgene Expression
Human cells contain hundreds of kinase enzymes that regulate several cellular processes, which likely include transgene delivery and expression. We identified several kinases that influence gene delivery and / or expression by performing a kinome-level screen in which, we identified small-molecule k...
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| Publicado no: | J Control Release |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8292636/ https://ncbi.nlm.nih.gov/pubmed/25681050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2015.01.036 |
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