Kinome wide functional screen identifies role of Polo-like kinase 1 (PLK1) in hormone-independent, ER-positive breast cancer

Estrogen receptor α (ER)-positive breast cancers initially respond to antiestrogens but eventually become estrogen-independent and recur. ER+ breast cancer cells resistant to long-term estrogen deprivation (LTED) exhibit hormone-independent ER transcriptional activity and growth. A kinome-wide siRNA...

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書誌詳細
出版年:Cancer Res
主要な著者: Bhola, Neil, Jansen, Valerie M., Bafna, Sangeeta, Giltnane, Jennifer M., Balko, Justin M., Estrada, Mónica V., Meszoely, Ingrid, Mayer, Ingrid, Abramson, Vandana, Ye, Fei, Sanders, Melinda, Dugger, Teresa C., Van Allen, Eliezer, Arteaga, Carlos L.
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297507/
https://ncbi.nlm.nih.gov/pubmed/25480943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-2475
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