ER+ breast cancers resistant to prolonged neoadjuvant letrozole exhibit an E2F4 transcriptional program sensitive to CDK4/6 inhibitors

PURPOSE: This study aimed to identify biomarkers of resistance to endocrine therapy in ER+ breast cancers (BC) treated with prolonged neoadjuvant letrozole. EXPERIMENTAL DESIGN: We performed targeted DNA and RNA-sequencing in 68 ER+ BC from patients treated with preoperative letrozole (median 7 mont...

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Publicado no:Clin Cancer Res
Main Authors: Guerrero-Zotano, Angel L., Stricker, Thomas P., Formisano, Luigi, Hutchinson, Katherine E., Stover, Daniel G., Lee, Kyung-min, Schwarz, Luis J., Giltnane, Jennifer M., Estrada, Valeria M., Jansen, Valerie M., Servetto, Alberto, Gavilá, Joaquín, Perez-Fidalgo, J. Alejandro, Lluch, Ana, Llombart, Antonio, Bayar, Mohamed A., Michiels, Stefan, André, Fabrice, Arnedos, Mónica, Guillem, Vicente, Ruiz, Amparo, Arteaga, Carlos L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690756/
https://ncbi.nlm.nih.gov/pubmed/29581135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-2904
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